Your treatment plan will be based on the type of liver cancer you have, the stage of the cancer, how well your liver works, your overall health, and the discussion between you and your healthcare professional.
Curative treatment aims to cure the disease by removing the tumor(s).
Curative treatments include:
- Liver transplant—may be possible if the cancer has not spread to other parts of the body and a compatible liver is found
- Surgery—can be used to remove 1 or more tumors, depending on the size and location of the tumors within the liver
- Percutaneous ethanol injection (PEI)—destroys tumors by injecting them with a form of alcohol (ethanol)
- Radiofrequency ablation (RFA)—destroys abnormal cells by heating them with radio waves. The radio waves travel through electrodes (small devices that carry electricity)
Noncurative treatment is used for patients with unresectable disease (cancer that cannot be treated with surgery).
The goal of this type of treatment is to make symptoms better and slow the growth of your cancer.
Noncurative treatment includes:
- Locoregional therapy, which consists of various minimally invasive procedures that are introduced directly into the tumor and cause tumor death, including:
- Transarterial chemoembolization (known as TACE)—a procedure in which chemotherapy drugs are injected into the blood vessels that feed the tumors. This delivers a high dose of chemotherapy into the tumor while lowering the blood supply that feeds the tumor
- Radiotherapy, which uses high-energy radiation to kill cancer cells and shrink tumors. There are 2 types of radiotherapy:
- External beam radiation therapy (EBRT)—uses a machine outside the body to deliver the radiation
- Internal radiation therapy—uses a radioactive substance, such as yttrium-90, that is injected near a liver tumor
- Systemic treatment, which is taken orally, interferes with the signaling pathways in the body that cause normal and cancerous cells to grow and multiply
- NEXAVAR is a noncurative systemic treatment only to be used in liver cancers that cannot be treated with surgery
For patients with liver cancer, a treatment plan may include any or all of the treatments above. Speak with your healthcare professional about how NEXAVAR, an oral medication, might fit into your treatment plan if you have liver cancer that cannot be treated with surgery.
NEXAVAR is an anticancer medicine used to treat a certain type of liver, kidney or thyroid cancer called:
- Hepatocellular carcinoma (HCC, a type of liver cancer), when it cannot be treated with surgery
- Renal cell carcinoma (RCC, a type of kidney cancer)
- Differentiated thyroid carcinoma (DTC, a type of thyroid cancer) that can no longer be treated with radioactive iodine and is progressing
NEXAVAR has not been studied in children.
Important Safety Information
Do not take NEXAVAR if you have a specific type of lung cancer (squamous cell) and receive carboplatin and paclitaxel or if you are allergic to sorafenib or any of the other ingredients in NEXAVAR.
Before starting NEXAVAR, tell your doctor if you have: allergies, heart problems (including a problem called "congenital long QT syndrome") or chest pain, bleeding or bruising problems, high blood pressure, any planned surgical procedures, lung cancer or are being treated for lung cancer, kidney problems in addition to kidney cancer, or liver problems in addition to liver cancer.
Tell your doctor if you are pregnant or plan to become pregnant and if you are breast-feeding or plan to breast-feed. It is not known if NEXAVAR passes into your breast milk. You and your doctor should decide if you will take NEXAVAR or breast-feed. You should not do both.
NEXAVAR may interact with certain other medicines and cause serious side effects so tell your doctor about all medicines you take including prescription and over-the-counter (OTC) medicines, vitamins, or herbal supplements. Especially tell your doctor if you are taking the following medicines: warfarin (Coumadin, Jantoven®), neomycin, St. Johns Wort, dexamethasone, phenytoin (Fosphenytoin sodium, Dilantin, Phenytek), carbamazepine (Carbatrol, Equetro, Tegretol, Teril, Epitol), rifampin (Rifater, Rifamate, Rifadin, Rimactane), rifabutin (Mycobutin), phenobarbital.
NEXAVAR may cause serious side effects, including:
- decreased blood flow to the heart and heart attack. Get emergency help right away and call your doctor if you have chest pain, shortness of breath, feel lightheaded or faint, have nausea or vomiting, or you are sweating a lot.
- bleeding problems. Bleeding is a common side effect of NEXAVAR that can be serious and sometimes lead to death. Tell your doctor if you have any bleeding or easy bruising while taking NEXAVAR.
- high blood pressure. High blood pressure is a common side effect of NEXAVAR and can be serious. Your blood pressure should be checked every week during the first 6 weeks of starting therapy and then regularly, thereafter. If your blood pressure is high, it should be treated.
- a skin problem called hand-foot skin reaction. This causes redness, pain, swelling, or blisters on the palms of your hands and soles of your feet. Your doctor may change your dose or stop treatment for a while.
- serious skin and mouth reactions. NEXAVAR can cause serious skin and mouth reactions which can be life-threatening. Tell your doctor if you have skin rash, blistering and peeling of the skin, blistering and peeling on the inside of your mouth.
- an opening in the wall of your stomach or intestines (perforation of the bowel). Tell your doctor right away if you get high fever, nausea, vomiting or abdominal (stomach) pain.
- wound healing problems. If you have a surgical or dental procedure, tell your doctor you are taking NEXAVAR. Your treatment may be stopped until after your surgery or until your wound heals.
- changes in the electrical activity of your heart called QT prolongation. QT prolongation can cause irregular heartbeats that can be life-threatening. Your doctor may do tests during your treatment with NEXAVAR to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an ECG. Tell your doctor right away if you feel faint, lightheaded, dizzy, or feel your heart beating irregularly or fast while taking NEXAVAR.
- inflammation of your liver (drug-induced hepatitis). NEXAVAR may cause liver problems that may lead to liver failure and death. Your doctor may stop your treatment with NEXAVAR if you develop changes in certain liver function tests. Call your doctor right away if you develop yellowing of the skin or white part of your eyes (jaundice), dark "tea-colored" urine, light-colored bowel movements (stools), worsening nausea, worsening vomiting, abdominal pain.
- birth defects or death of an unborn baby. Avoid becoming pregnant while taking NEXAVAR and for at least 2 weeks after stopping your treatment. Men and women should use birth control during and at least 2 weeks after NEXAVAR therapy. Talk with your doctor about effective birth control methods. Call your doctor right away if you become pregnant.
- change in thyroid hormone levels. If you have differentiated thyroid carcinoma, you can have changes in your thyroid hormone levels when taking NEXAVAR. Your doctor should monitor thyroid hormone levels every month and may need to increase your dose of thyroid medicine.
The most common side effects with NEXAVAR include: diarrhea (frequent or loose bowel movements); tiredness; infection; hair thinning or patchy hair loss; rash; weight loss; loss of appetite; nausea; stomach (abdominal) pain; low blood calcium levels in people with differentiated thyroid cancer.
Tell your doctor if you have any side effects that bother you or do not go away. These are not all the possible side effects of NEXAVAR. Ask your doctor or pharmacist for more information.
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For important risk and use information about NEXAVAR, please see the full Prescribing Information.