About Nexavar for Kidney Cancer

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Your Therapy with Nexavar

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A Targeted Therapy

Nexavar is a prescription, anticancer medicine used to treat adults with kidney cancer. Nexavar is a multiple kinase inhibitor, one of a new class of therapies often called targeted therapy. The growth of new blood vessels and the growth of new cells are 2 processes which do not function normally in tumors. Nexavar is designed to interfere with these 2 processes. By reducing the blood supply of the tumor and by slowing tumor growth, Nexavar may prevent the growth and spread of cancer. These processes can also be important to normal cells, so targeted therapies like Nexavar may affect some normal cells as well.


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Indications and Usage

NEXAVAR is an anticancer medicine used to treat a certain type of liver or kidney cancer called:
- Hepatocellular carcinoma (HCC), when it cannot be treated with surgery
- Renal cell carcinoma (RCC, a type of kidney cancer).

Important Safety Information

NEXAVAR may cause birth defects or death of an unborn baby. Avoid becoming pregnant while taking NEXAVAR and for at least 2 weeks after stopping your treatment. Men and women should use birth control during and at least 2 weeks after NEXAVAR therapy. Call your doctor right away if you become pregnant. Do not breastfeed while taking NEXAVAR as this medication may be passed through breast milk.

Before starting NEXAVAR, tell your doctor if you have: allergies; heart problems or chest pain; bleeding or bruising problems; high blood pressure; or kidney or liver problems. NEXAVAR may interact with certain other medicines so tell your doctor about all medicines you take including prescription and over-the-counter (OTC) medicines, vitamins, or herbal supplements.It is especially important to tell your doctor if you take warfarin (Coumadin).

NEXAVAR may cause serious side effects, including:

-Decreased blood flow to the heart and heart attack. Get emergency help if you have chest pain, shortness of breath, feel lightheaded or faint, have nausea or vomiting, or you are sweating a lot.

-Bleeding problems. Tell your doctor if you have any bleeding or easy bruising while taking NEXAVAR.

-High blood pressure. Your blood pressure should be checked every week during the first 6 weeks of starting therapy and then regularly, thereafter. If your blood pressure is high, it may need to be treated.

-A skin problem called hand-foot skin reaction. This causes redness, pain, swelling or blisters on the palms of your hands and soles of your feet. Your doctor may change your dose or stop treatment for a while.

-Perforation of the bowel. Tell your doctor right away if you get high fever, nausea, vomiting or abdominal pain.

-Wound healing problems. If you have a surgical or dental procedure, tell your doctor you are taking NEXAVAR. Your treatment may be stopped until after your surgery or until your wound heals.

Other side effects with NEXAVAR can include: rash, redness, itching or peeling skin; hair thinning or loss; diarrhea; nausea/vomiting; mouth sores; weakness; loss of appetite; numbness, tingling or pain in hands and feet; abdominal pain; tiredness; or weight loss. Tell your doctor if you have any side effects that bother you or do not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For important risk and use information, please see the patient prescribing information.