Nexavar® (sorafenib): Possible Side Effects-Nexavar-us.com

IMPORTANT SAFETY INFORMATION

Do not take NEXAVAR if you have a specific type of lung cancer (squamous cell) and receive carboplatin and paclitaxel or if you are allergic to sorafenib or any of the other ingredients in NEXAVAR. Before starting NEXAVAR, tell your doctor if you have: allergies, heart problems (including a problem called “congenital long QT syndrome”) or chest pain, bleeding or bruising problems, high blood pressure, any planned surgical procedures, lung cancer or are being treated for lung cancer, kidney problems in addition to kidney cancer, or liver problems in addition to liver cancer. Tell your doctor if you are pregnant or plan to become pregnant and if you are breast-feeding or plan to breast-feed. It is not known if NEXAVAR passes into your breast milk. You and your doctor should decide if you will take NEXAVAR or breast-feed. You should not do both.
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Possible Serious Side Effects

NEXAVAR may cause serious side effects, including:

  • Decreased blood flow to the heart and heart attack. Get emergency help right away and call your doctor if you have chest pain, shortness of breath, feel lightheaded or faint, have nausea or vomiting, or you are sweating a lot
  • Bleeding problems. Bleeding is a common side effect of NEXAVAR that can be serious and sometimes lead to death. Tell your doctor if you have any bleeding while taking NEXAVAR
  • High blood pressure. High blood pressure is a common side effect of NEXAVAR and can be serious. High blood pressure is a common side effect of NEXAVAR and can be serious. Your blood pressure should be checked every week during the first 6 weeks of starting therapy and then regularly, thereafter. If your blood pressure is high, it should be treated
  • A skin problem called hand-foot skin reaction. This causes redness, pain, swelling, or blisters on the palms of your hands or soles of your feet. If you get this side effect, your doctor may change your dose or stop treatment for a while
  • Serious skin and mouth reactions. NEXAVAR can cause serious skin reactions which can be life-threatening. Tell your doctor if you have:
    • Skin rash
    • Blistering and peeling of the skin
    • Blistering and peeling on the inside of your mouth
  • An opening in the wall of your stomach or intestines (perforation of the bowel). Tell your doctor right away if you get high fever, nausea, vomiting, or severe stomach (abdominal) pain
  • Wound healing problems. If you have a surgical or dental procedure, tell your doctor you are taking NEXAVAR. Your treatment may be stopped until after your surgery or until your wound heals
  • Changes in the electrical activity of your heart called QT prolongation. QT prolongation can cause irregular heartbeats that can be life-threatening. Your doctor may do tests during your treatment with NEXAVAR to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an ECG. Tell your doctor right away if you feel faint, lightheaded, dizzy or feel your heart beating irregularly or fast while taking NEXAVAR
  • Inflammation of your liver (drug-induced hepatitis). NEXAVAR may cause liver problems that may lead to liver failure and death. Your doctor may stop your treatment with NEXAVAR if you develop changes in certain liver function tests. Call your doctor right away if you develop:
    • Yellowing of the skin or white part of your eyes (jaundice)
    • Dark “tea-colored” urine
    • Light-colored bowel movements (stools)
    • Worsening nausea
    • Worsening vomiting
    • Abdominal pain
  • Birth defects or death of an unborn baby. Avoid becoming pregnant while taking NEXAVAR and for at least 2 weeks after stopping your treatment. Men and women should use birth control during and at least 2 weeks after NEXAVAR therapy. Talk with your doctor about effective birth control methods. Call your doctor right away if you become pregnant
  • Change in thyroid hormone levels. If you have differentiated thyroid cancer, you can have changes in your thyroid hormone levels when taking NEXAVAR. Your doctor should monitor thyroid hormone levels every month and may need to increase your dose of thyroid medicine

Here are some of the most common side effects people get when they take NEXAVAR:

  • Diarrhea (frequent or loose bowel movements)
  • Tiredness
  • Infection
  • Hair thinning or patchy hair loss
  • Rash
  • Weight loss
  • Loss of appetite
  • Nausea
  • Stomach (abdominal) pain
  • Low blood calcium levels in people with differentiated thyroid cancer

Tell your doctor if you have any side effects that bother you or do not go away. These are not all the possible side effects of NEXAVAR. Ask your doctor or pharmacist for more information.

If you experience any symptom that bothers you or does not go away, contact your doctor or health care team, or seek medical attention as soon as possible.

These are not all the side effects of Nexavar. Ask your doctor or pharmacist for more information. Please talk to your doctor about how to help manage your side effects.

Remember: your health care team is the best source of information regarding you and your health.

How your doctor may manage side effects

Your health care team has different ways to help manage some of the side effects of Nexavar. One approach your doctor may take is to change your dose or stop your treatment temporarily. This is a common way to manage certain side effects, and is generally not a cause for concern. Be sure to discuss any questions that you have with your doctor. In fact, changing your dose or stopping your treatment temporarily may be the best way to get you back on therapy. However, your doctor may need to permanently stop your treatment with Nexavar due to side effects.